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EU-OSHA’s multilingual thesaurus of occupational safety and health terminology lists words grouped together in a hierarchy. It includes synonyms and antonyms of those words and some definitions.
62146E
capability in causing tumor formation
Thus, the emphasis of this guidance is on the need to estimate systemic exposure, to parent compound and/or metabolite(s) at appropriate dose levels and at various stages of an oncogenicity study, so that the findings of the study may be considered in the perspective of comparative exposure for the animal model and humans.
EMA, ICH Topic S 3 A Toxicokinetics: A Guidance for Assessing Systemic Exposure in Toxicology Studies, http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideli…