Musculoskeletal disorders (MSDs) are the most common work-related health problem in Europe. Tackling MSDs means taking action in the workplace. First, there are preventative steps that have to be taken. But for workers who already have MSDs, the challenge is to maintain their employability, keep them working and, if necessary, reintegrate them into the workplace. This is the European Agency for Safety and Health at Work’s ’Back to Work’ report, which focuses on the retention, reintegration and rehabilitation of workers with MSDs. It comes in two parts: a literature review on the effectiveness of work-related interventions, and an overview of policy initiatives in Europe and at the international level.