A connected European Digital Single Market that removes regulatory barriers between nations, improves digital infrastructures and enhances digital skills is a key priority for the European Commission. In support of this and in line with the EU Strategic Framework on Safety and Health 2014-2020, this Foresight project was carried out by EU-OSHA in response to the call to ‘anticipate possible negative effects of new technologies and changes in work organisation on workers’ health and safety’. It also backs the principles of the European Pillar of Social Rights, which constitutes the broader policy framework for action in the area of social protection and basic rights and includes the right to fair working conditions.