Musculoskeletal disorders (MSDs) are the most common work-related problem in Europe - 25 % of the EU-27 workers report suffering from backache and 23 % complain about muscular pains. First, there are preventive steps that have to be taken. But for workers who already have MSDs, the challenge is to maintain their employability, keep them working and, if necessary, reintegrate them into the workplace. This fact sheet highlights the key findings of the European Agency for Safety and Health at Work's prevention report, which focuses on the prevention of MSDs and the development and progress made in this area since the previous MSDs campaign in 2000. The report consists of two parts: a state-of-the-art review of the research literature with respect to work-related interventions preventing MSDs risks; and 15 case studies demonstrating how the problems have been solved at the workplace level.