Endocrine disruptors are chemicals that can alter the hormonal system; specifically, they interfere with natural hormones. This may lead to problems with hormone production and their effects on health include damage to the male reproductive system and influencing the development of an embryo. This guidance is aimed at improving working conditions and provides users with general information on the effects of endocrine disruptors. It provides a step-by-step substitution process for chemicals with endocrine disruptor effects. It also contains a list of about 500 substances that are endocrine disrutors.